Compile Data Set for Download or QSAR
maximum 50k data
Found 327 of ic50 for VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D
having polymerids = 50000704,50001262 and
complexids = 50000903,50024737,50000735
LigandPNGBDBM50227255(CHEMBL102907)
Affinity DataIC50:  0.00810nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227481(CHEMBL286157)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227261(CHEMBL317044)
Affinity DataIC50:  0.0130nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227259(CHEMBL441428)
Affinity DataIC50:  0.0150nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227474(CHEMBL286598)
Affinity DataIC50:  0.0170nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227478(CHEMBL37402)
Affinity DataIC50:  0.0220nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227256(CHEMBL103806)
Affinity DataIC50:  0.0270nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227480(CHEMBL37899)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227476(CHEMBL204616)
Affinity DataIC50:  0.0330nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227479(CHEMBL35368)
Affinity DataIC50:  0.0450nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227473(CHEMBL1099207)
Affinity DataIC50:  0.0460nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227475(CHEMBL285868)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227257(CHEMBL321999)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50478489(CRAMBESCIDIN 816 HYDROCHLORIDE | Crambescidin 816 ...)
Affinity DataIC50:  0.150nMAssay Description:Antagonist activity at voltage-dependent L-type calcium channel in mouse neurobalstoma-rat glioma NG 108-15 hybrid cells assessed as inhibition of KC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50227262(CHEMBL105444)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of voltage-gated L-type Ca channel (species unknown)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227477(CHEMBL35123)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel of guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50029417(CHEMBL277363 | [4-(4-Methoxy-phenyl)-4H-benzo[b]py...)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50422202(CHEMBL24662)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataIC50:  1nMAssay Description:In vitro vasorelaxant activity (calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227260(CHEMBL319033)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228791(CHEMBL329897)
Affinity DataIC50:  1.5nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228797(CHEMBL89260)
Affinity DataIC50:  1.70nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228807(CHEMBL2092901)
Affinity DataIC50:  2nMAssay Description:In vitro vasorelaxant activity (calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227258(CHEMBL102498)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228801(CHEMBL89049)
Affinity DataIC50:  2.60nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50018796(2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridi...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory concentration for L-type [Ca2+] channels was measured through displacement of [3H]nitrendipine on rat cortex homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory concentration for L-type [Ca2+] channels was measured through displacement of [3H]nitrendipine on rat cortex homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228811(CHEMBL84906)
Affinity DataIC50:  2.70nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227254(CHEMBL318521)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of [3H]nitrendipine binding to guinea pig ileal longitudinal smooth muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228808(CHEMBL86415)
Affinity DataIC50:  3.10nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50422200(CHEMBL278804)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228810(CHEMBL89904)
Affinity DataIC50:  3.60nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50227246(CHEMBL3392282)
Affinity DataIC50:  4nMAssay Description:In vitro vasorelaxant activity (calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50422196(CHEMBL25512)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228804(CHEMBL89175)
Affinity DataIC50:  5.20nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50072809(4-[2-(4-Cyano-furazan-3-ylmethoxy)-phenyl]-2,6-dim...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration for L-type [Ca2+] channels was measured through displacement of [3H]nitrendipine on rat cortex homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50317817(3-cyclohex-2-enyl 5-methyl 2,6-dimethyl-4-(3-nitro...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at rat Cav1.3 expressed in HEK293 cells assessed as inhibition of voltage pulse-induced calcium current by FLIPR calcium 4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50101817(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50317813(3-ethyl 5-(2-(methacryloyloxy)ethyl)2,6-dimethyl-4...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at rat Cav1.3 expressed in HEK293 cells assessed as inhibition of voltage pulse-induced calcium current by FLIPR calcium 4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50317802(3-allyl 5-methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at rat Cav1.3 expressed in HEK293 cells assessed as inhibition of voltage pulse-induced calcium current by FLIPR calcium 4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50317840(CHEMBL1099188 | diethyl 4-(2,3-difluorophenyl)-2,6...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at rat Cav1.3 expressed in HEK293 cells assessed as inhibition of voltage pulse-induced calcium current by FLIPR calcium 4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50317833(3-methyl 5-(3-phenylbutyl)2,6-dimethyl-4-(3-nitrop...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at rat Cav1.3 expressed in HEK293 cells assessed as inhibition of voltage pulse-induced calcium current by FLIPR calcium 4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228812(CHEMBL315125)
Affinity DataIC50:  11nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50317836(3-methyl 5-(3-phenoxypropyl)2,6-dimethyl-4-(3-nitr...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at rat Cav1.3 expressed in HEK293 cells assessed as inhibition of voltage pulse-induced calcium current by FLIPR calcium 4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50422191(CHEMBL24998)
Affinity DataIC50:  12nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50317835(3-(2-(benzyloxy)ethyl)5-methyl 2,6-dimethyl-4-(3-n...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at rat Cav1.3 expressed in HEK293 cells assessed as inhibition of voltage pulse-induced calcium current by FLIPR calcium 4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50228796(CHEMBL330707)
Affinity DataIC50:  14nMAssay Description:In vitro vasorelaxant activity (voltage-gated calcium channel blocking activity) was determined with potassium-depolarized rabbit thoracic aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Rattus norvegicus)
Universita' Degli Studi Di Siena

Curated by ChEMBL
LigandPNGBDBM50317826(3-furan-2-ylmethyl 5-methyl 2,6-dimethyl-4-(3-nitr...)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at rat Cav1.3 expressed in HEK293 cells assessed as inhibition of voltage pulse-induced calcium current by FLIPR calcium 4 assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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